TB Whole Genome Sequencing Analysis: Principles and Applications (TB2022)

Event Date : 2022-07-04 - 2022-07-07

Venue : Siriraj Medical Research Center (SiMR) Building, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Website : http://bdm.si.mahidol.ac.th/TB2022

Tuberculosis (TB) is a global health problem.  The World Health Organization (WHO) reported in 2018 that there were about 10 million new TB patients and 1.4 million died from TB.  The problem is increasing from multidrug-resistant TB (MDR-TB) with more than 500,000 patients estimated to be found in the world.  Many ASEAN countries including Thailand, Myanmar, Indonesia, Vietnam, Cambodia, Laos and the Philippines are classified by WHO as high TB burden countries.  Moreover, Thailand, Myanmar and Indonesia were included in 14 countries with high number of TB patients, high MDR-TB and high TB-HIV co-infected patients which should rapidly implement strategies for ending TB.

WHO recommends every high TB burden countries to rapidly diagnose TB patient, treat them with appropriate drugs timely until cure to reduce TB transmission in the community.  Novel molecular laboratory techniques such as GeneXpert MTB/Rif or MTB/Rif Ultra, line probe assay (LPA) should be used in TB diagnosis and determined drug susceptibility both for first- and second-line antituberculosis drugs.  In 2018 WHO proposed the whole genome sequence (WGS) obtained from the high through put next generation sequencing platform for rapid prediction of susceptibility to anti-TB drugs, investigation of TB transmission in house, in community, in country and among neighboring countries. This should have impact on better prevention of TB transmission and more effective in TB control.  Due to these reasons the Division of Bioinformatics and Data Management for Research, Research Group and Research Network Division and Drug Resistant Tuberculosis Fund, Siriraj Foundation under the patronage of pass HRH Princess Galyanivadhana, Faculty of Medicine Siriraj Hospital, Mahidol University collaborates with the London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom arrange the 4 days training workshop on TB WGS analysis for human resource strengthening in the country and in the region.

OBJECTIVE

1. To strengthen human resource in public health and academic science in Thailand and ASEAN by distribution of high through put sequencing technology both principles and their applications on tuberculosis work.

2.  To provide in silico practice on whole genome sequencing analysis of TB isolates and be able to analyze their own data in their countries in the future.

3. To chair and to exchange knowledge in TB WGS analysis with experts from UK and building TB ASEAN Research Network in the future

Organized by : Division of Bioinformatics and Data Management for Research, Research Group and Research Network, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.